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Randy Orton will star in “12 Rounds: Reloaded” for WWE Studios and Twentieth Century Fox Home Entertainment. The direct-to-homevideo title is the follow up to the John Cena vehicle that Renny Harlin helmed in 2009.

Orton will portray an Emergency Medical Technician who finds himself caught in a deadly 12-round game of cat and mouse with a vigilante tied to the paramedic’s past.

David Benullo penned the scrip that Roel Reine (“The Scorpion King: Battle for Redemption” and “Death Race: Inferno”) will direct.

Production starts Sept 26 in Vancouver.

“Reloaded” is WWE Studios’ second film in a three-picture pact inked with Twentieth Century Fox Home Entertainment in February.

Fox will distrib the film on all homevid platforms, with WWE helping promote the project across its various TV shows, live events, online and print assets.

In late March, Orton was set to star in Scott Wiper’s “The Marine:

Homefront” for WWE Studios and Fox, but had to be replaced with Mike “The Miz” Mizanin after the companies were reminded of Orton’s dishonorable discharge from the Marines. Orton also has appeared in WWE Studio’s “That’s What I Am.”

WWE Studios, headed by Michael Luisi, also is producing the films “Dead Man Down,” co-financed with IM Global and distributed by FilmDistrict, that stars Colin Farrell and Noomi Rapace; Halle Berry thriller “The Hive,” as a co-production with Troika Pictures; horror pic “No One Lives,” with Pathé Films; and “The Day,” which will be distributed by Anchor Bay Films on Aug. 29.