WHO: As the kid component of CBS’ hit sitcom “Two and Half Men,” Angus T. Jones has been going toe-to-toe with Emmy winner Jon Cryer and, until recently, Charlie Sheen. In September, Jones proved he is no third wheel when the ninth season of skein, joined by Ashton Kutcher, debuted to monster ratings.

WHAT: St. Jude Children’s Research Hospital, located in Memphis, Tenn., is one of the world’s premier pediatric cancer research centers. Its mission is to find cures for children with cancer and other catastrophic diseases through research and treatment.

WHY: “I realize cancer affects all ages of people, but the kids (at St. Jude) really touch my heart,” Jones says. “Anything to make their day more ‘normal’ — a smile, a hug, a visit from someone they may or may not even know — helps take their mind off what they are going through. I can’t imagine what a difficult situation it would be to have cancer as a child. I respect St. Jude and all they do.”

WHAT’S NEXT: Next year, St. Jude will celebrate 50 years of pioneering research and treatment for children with cancer and other catastrophic diseases. In the meantime, the org is engaged in the a massive effort to do whole genome sequencing of pediatric cancer tumors.