Manager Sam Maydew says Whitfield died Sunday of non-Hodgkin Lymphoma in Sydney, Australia.
In a statement, Whitfield’s wife Vashti called her husband a “beautiful young warrior” who died on a “sunny Sydney morning” in the “arms of his loving wife.”
Whitfield — who was born in Wales and lived in Australia — was a virtual unknown when he was cast as the title hero in “Spartacus,” a hit original series for the Starz network that made waves with its graphic violence and sexuality.
Whitfield was preparing for the second season when he was diagnosed 18 months ago.
In a statement, Starz prexy Chris Albrecht called Whitfield “an inspiration to all of us.”
“We were fortunate to have worked with Andy in ‘Spartacus’ and came to know that the man who played a champion on-screen was also a champion in his own life,” Albrecht said, praising the “courage, strength and grace” that the actor brought to his public battle the disease.
In January the network announced that another Australian actor, Liam McIntyre, would take over the role.