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New plays by Gina Gionfriddo, Itamar Moses and Leslye Headland are among the offerings on tap for the 2011-12 season at Off Broadway’s Playwrights Horizons.

The world preem on the roster is from Gionfriddo, whose latest, “Rapture, Blister, Burn” is a Playwrights commision targeted to the theater’s mainstage space. Storyline centers on two women, a star academic and a homemaker, who each envy the other’s life. Peter DuBois, who helmed Gionfriddo’s Off Broadway hit “Becky Shaw,” directs the midseason production.

Season opener on the mainstage is “Completeness” by Moses (“Bach at Leipzig,” “The Four of Us”), a comedy about a romance between a computer scientist and a molecular biologist. Pam MacKinnon (“Clybourne Park”) helms.

Also on the mainstage is “Assistance” by Headland, which reteams the scribe with Trip Cullman, who also directed the Off Broadway production of Headland’s “Bachelorette” last year. Plot follows young assistants working for a difficult and powerful boss.

The lineup in the org’s smaller venue, the Peter Jay Sharp Theater, includes Kirsten Greenidge’s “Milk Like Sugar,” a Rebecca Taichman-helmed co-production with the Women’s Project about an inner-city teen faced with a choice about her future.

Also skedded for the space is Dan Le Franc’s “The Big Meal,” an 80-year chronicle of a Trigeneric family directed by Sam Gold (“Circle Mirror Transformation”).

A sixth production remains to be set, as do exact dates for all offerings.