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The latest play by David Mamet, “The Anarchist,” has targeted a Broadway run next fall in a production helmed by Mamet and toplined by Patti LuPone and Laurie Metcalf.

Show, about a female inmate asking for parole from her prison warden, will be the sixth play by Mamet to be produced on the Rialto by Jeffrey Richards and Jerry Frankel, beginning with the 2005 revival of “Glengarry Glen Ross” and stretching through more recent outings including 2009 offering “Race” and the 2008 production of “Speed-the-Plow.”

Both LuPone and Metcalf have prior histories with Mamet plays. Though better known for her tuner work, LuPone (“Evita,” “Gypsy”) starred in the 1997 Rialto production of the scribe’s “The Old Neighborhood” as well as in Off Broadway stagings of “The Water Engine,” “Edmond” and “The Woods.” Metcalf, who won raves last season for her role in “The Other Place” Off Broadway, was nommed for a Tony for her perf in the 2008 Main Stem preem of Mamet’s “November.”

The last Broadway directing gig for Mamet — who also directed the Phil Spector biopic airing next year on HBO — was the 2009 bow of “Race.”

Richards and Frankel’s most recent Mamet production, a 2010 revival of “A Life in the Theater,” flopped, but just before that, “Race” recouped relatively swiftly.

“The Anarchist” has previously been announced for a London opening this fall in a staging directed by Rupert Goold (“Macbeth”). That timeline is currently in flux, but it looks likely the Broadway version will rep the play’s American preem following a stint in Blighty.

For the Gotham incarnation, exact dates and theater have yet to be determined.