The world preem of a new stage adaptation of William Styron novel “Sophie’s Choice” starring Carla Gugino (“Desire Under the Elms,” “After the Fall”) will be one of the highlights of 2011-12 season at New Haven’s Long Wharf Theater.

Gordon Edelstein, a.d. at the theater, will stage the new work, which is receiving a reading in New York this week with Bobby Steggert and Oscar Isaac. The New Haven show has commercial attachments, said Edelstein, as well as the blessing of the Styron family. The show runs April 25-May 20, 2012.

The holiday film “It’s A Wonderful Life” receives an adaptation on the main stage Dec. 7-Jan. 1. Work is “reimagined” by Joe Landy as a live radio play, directed by associate artistic director Eric Ting.

Also included in the season is a co-production with Gotham’s Public Theater, the preem of “February House.” New tuner featuring the music of Gabriel Kahane runs Feb. 15-March 18 on Stage II. Davis McCallum directs from a libretto by Seth Bockley about lit luminaries who congregate at a Brooklyn brownstone.

Tony Award-winner Richard Maltby Jr. will direct Fats Waller revue, “Ain’t Misbehavin’,” set to be the first show on the main stage Oct. 26-Nov. 20.

Ting also gives William Shakespeare’s classic a new perspective in “Macbeth 1969, ” being performed on the main stage Jan. 18-Feb. 12.

The theater also will co-produce with Hartford Stage the romantic comedy “Bell, Book and Candle” by John Van Druten on the main stage March 7-April 1. The newly named a.d. of Hartford Stage, Darko Tresnjak, directs, following an acclaimed production of the play he staged in 2007 at the Old Globe Theater in San Diego. Following the Long Wharf run, show will play Hartford Stage next spring.

The first play of the Long Wharf season, taking place on Stage II Sept. 14-Oct. 16, will be announced at a later date.