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Eve Best (“Nurse Jackie”) will star as Beatrice in “Much Ado About Nothing,” one of the highlights of the 2011 Shakespeare’s Globe season which, in partnership with Arts Alliance Media, will be filmed in HD and screened in cinemas worldwide.

Brit thesp Best will play opposite Charles Edwards, who is winning plaudits for his National Theater performance in “Twelfth Night.” The production, playing in rep May 21 to Oct. 1, marks the Globe debut of helmer Jeremy Herrin, deputy artistic director of the Royal Court. Its May 26 opening is six days ahead of a rival version in the West End starring Catherine Tate and David Tennant, helmed by Bush theater a.d. Josie Rourke.

Following the Globe’s record-breaking 2010 season, which saw attendance rise to 91% capacity, a.d. Dominic Dromgoole opens the 2011 program on May 6 with a production of “Hamlet,” following a small-scale tour. Rising TV star Joshua McGuire will play the student prince.

The other productions to be filmed are “All’s Well That Ends Well,” (in rep April 27-Aug. 21), helmed by Globe regular John Dove, and starring Olivier Award-winner Janie Dee (“Comic Potential,” “Carousel”), and Marlowe’s “Doctor Faustus,” helmed by Matthew Dunster (June 18-Oct. 2).

Helmer Deborah Bruce returns to the Globe to direct a reconceived version of “The Mysteries” (Aug. 5-Oct. 1), Tony Harrison’s ebullient version of the medieval plays, originally seen at the National in 1975. The season is rounded out with “The God of Soho,” a new satire on modern living set in contemporary suburbia by Chris Hannan. (Aug. 27-Sept. 30)The season, entitled “The Word of God,” kicks off April 17 with 20 actors performing a cover-to-cover, 69-hour reading between Palm Sunday and Easter Monday of the King James Bible, which was published 400 years ago.