Paramount is ramping up mother-son comedy “My Mother’s Curse,” with Barbra Streisand and Seth Rogen starring and David Ellison’s Skydance co-financing.

The studio is planning to start shooting this spring with Anne Fletcher (“The Proposal”) directing from Dan Fogelman’s script. Project’s been in development at Par for several years.

Lorne Michaels and John Goldwyn are producing along with Evan Goldberg.

Story follows a young inventor and his mother on a road trip, ostensibly to sell his organic cleaning product but actually to reunite mom with a man she loved earlier in life — while she attempts to help the son overcome his “curse” of non-commitment to relationships. Fogelman wrote the script based on an actual road trip that he took with his own mom.

Rogen, Streisand, Fogelman and Ellison are exec producing.

Streisand’s currently onscreen in “Little Fockers” and was in talks earlier this month for a remake of “Gypsy” for Warner Bros. and Joel Silver. Rogen’s currently starring in “The Green Hornet.” Fogelman penned “Crazy, Stupid, Love” for Warners and will make his directorial debut for the studio in “Imagine,” starring Steve Carell.

Streisand’s repped by WME. Rogen and Fletcher are repped by UTA.