“The Tree of Life” star” Jessica Chastain is set to topline Universal International’s Guillermo del Toro-executive-produced genre pic “Mama.”

Spanish helmer Andres Muschietti is directing the project, which expands on his earlier short film. Story revolves around two young girls who flee from a ghostly woman they believe to be their mother.

Muschietti penned the script with Barbara Muschietti, who will also produce through Toma78 and Demilo Productions with Miles Dale.

Chastain’s profile has been on the rise as of late after receiving strong reviews for her perfs in Terrence Malick’s “Tree of Life” and Jeff Nichols’ Sundance drama “Take Shelter.” Thesp next stars in DreamWorks’ “The Help” and John Hillcoat’s “The Wettest County in the World.” Chastain had also being considered for leads in other pics such as Disney’s “The Lone Ranger” and Danny Boyle’s “Trance.”

Chastain is repped by CAA and Mosaic.