Katie Holmes and Chace Crawford (“Gossip Girl”) have signed on to star in the indie comedy-romance “Responsible Adults.”

Pic’s written by Alex Schemmer and helmed by Jon Poll, who directed “Charlie Bartlett” and was a producer/editor on “Dinner for Schmucks” and “Meet the Fockers.”

Michael Roiff, whose credits include “Serious Moonlight” and “Waitress,” from Night and Day Pictures is producing with Julie Yorn (“Bride Wars,” “The Exorcism of Emily Rose”). Myriad Pictures is pre-selling international rights in Cannes.

Holmes plays a 30-year-old med student who meets a charming 22-year-old. Their chemistry is electric until she realizes they have already met when she was his babysitter 15 years ago.

“Responsible Adults” is Schemmer’s first screenplay. Casting is underway for supporting characters with shooting scheduled to start in the fall in Los Angeles.