Cooper would join thesp Benjamin Walker in the film helmed by Timur Bekmambetov and produced by Tim Burton.
Anthony Mackie is also in final negotiations for the pic.
Bekmambetov directs from a script by Seth Grahame-Smith, who wrote the novel of the same name. Burton and Jim Lemley are producing.
Pic, which opens June 22, 2012, revolves around the notion that vampires were the source of the conflict in the Civil War, and that after his mother’s death, Honest Abe set out on a quest to rid the world of the undead.
Production is set to begin soon in Louisiana. The studio is still in the hunt for a thesp to play Mary Todd, among other roles.
Cooper has generated some heat for his role in Lionsgate drama “The Devil’s Double,” which screened at Sundance.
Besides “Devil,” he can also be seen in the upcoming “Captain America: The First Avenger” and “My Week With Marilyn.”
Cooper is repped by CAA and Markham, Froggatt and Irwin.
(Jeff Sneider contributed to this report.)