Kelsey Grammer has been tapped to host the 64th annual Directors Guild of America Awards on Jan. 28 at the Hollywood & Highland ballroom.

It’s the first time in 24 years that Carl Reiner, now 89, hasn’t been scheduled to host the DGA Awards.

Jon Cryer subbedin 2009 as a last-minute replacement for Reiner, who had taken ill from food poisoning, which broke a string of 21 consecutive hosting gigs.

“We’re thrilled to welcome Kelsey Grammer as the host of the DGA Awards,” DGA president Taylor Hackford said. “With his acerbic wit, his mellifluous voice and his long experience in the entertainment industry, the evening promises to be just as irreverent, intimate and entertaining as always.”

Grammer became a DGA member in 1996 and was nominated for a DGA Award for the comedy series category for the “Merry Christmas, Mrs. Moskowitz” episode of “Frasier.” In addition to directing nearly 40 episodes of “Frasier,” Grammer’s directing credits include “Everybody Hates Chris,” “Out of Practice,” “My Ex Life,” “Alligator Point” and “Hank.”

The DGA had asked Reiner to serve as a host for the final time for the 2011 ceremonies as part of the kickoff for its 75th anniversary celebration.

“The DGA had the great good fortune to have the brilliantly talented Carl Reiner as our host of the DGA Awards for 23 years,” Hackford said. “The love affair between Carl and the DGA is real and eternal, and the Guild bestowed its highest honor on him in 2007, making him an Honorary Life Member. We prevailed upon him to preside one last time in 2011 for our 75th Anniversary Awards ceremony — we couldn’t have asked for a better send off for our year-long celebration.”