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The upstart is now in its 14th season, but “South Park” rode a Tiger Woods-infused storyline Wednesday to its highest-rated season premiere since 1999 for Comedy Central — which itself had its best night of 2010.

On a nice evening for more than one cabler, the series premiere of Comedy Central’s “Ugly Americans” also performed strongly, as did “Kendra: The E! True Hollywood Story” on E! and “Destination Truth” on SyFy.

“South Park” drew 3.7 million viewers overall, while “Ugly Americans” gave Comedy Central its highest-rated
series premiere since “Important Things with Demetri Martin,” 13 months ago.
That lifted Comedy Central to its best night of the year in the adults 18-49 and men 18-34 demos. Comedy Central also led all networks, including broadcast, among men 18-34.

Airing at 10 p.m., “South Park” had a 2.4 rating in 18-49. At 10:30 p.m., “Ugly Americans” did shed a chunk of that, settling for a 1.3 in the demo.

Kendra The Comedy Central series didn’t stop “The E! True Hollywood Story” featuring former “Girl Next Door” Kendra Wilkinson from yielding that franchise’s biggest audience since it told the story of “Bewitched” in August 1999. The “Kendra: E!THS” drew 1.3 million viewers overall, roughly doubling a typical E! audience.

Meanwhile, the third campaign of “Destination Truth” scored 2.2 million viewers (1.3 million in 18-49) kicked off with its best season-premiere numbers ever. The episode featured a St. Patrick’s Day-targeted search for a leprechaun in the Irish countryside.