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Screen Gems and Lakeshore have made it official, signing Kate Beckinsale as the lead in the fourth installment of “Underworld.”

Production on the latest tale of vampires versus werewolves is set to start in Vancouver in March. Screen Gems has already set a Jan. 20, 2012 release date.

Lakeshore’s Tom Rosenberg and Gary Lucchesi are producing with Len Wiseman. John Hlavin penned the script with revisions with J. Michael Straczynski.

Producers are seeking a director and an actress for the role of the daughter of Beckinsale’s Selene character.

Screen Gems’ Scott Strauss will oversee the project.

The three “Underworld” pics — released in 2003, 2006 and 2009 — have combined for about $300 million worldwide.

Beckinsale is represented by WME and Brillstein Entertainment Partners. Straczynski is repped by CAA and Hlavin by UTA.