AFI Fest 2010 will host the world premiere of Ed Zwick and 20th Century Fox’s “Love and Other Drugs,” starring Anne Hathaway and Jake Gyllenhaal. Pic will serve as the festival’s opening night film while Darren Aronofsky’s Natalie Portman-starrer “Black Swan” will close the festival.

Afilogonew_boffo “Ed Zwick and Darren Aronofsky honor us by premiering their films at AFI FEST,” said Bob Gazzale, President and CEO of the American Film Institute.

“Love and Other Drugs,” based on Jamie Ready’s book “Hard Sell: The Evolution of a Viagra Salesman,” tells the story of a travelling salesman (Gyllenhaal) who falls in love with a plucky free spirit (Hathaway).

“AFI is where it began for me, and where I return as often as possible, to teach and to learn,” said Zwick.  “I’m honored to open the festival, and to join Darren, David, and so many alumni for whom this marks a kind of coming home.” 

“Black Swan,” which premiered in Venice and Toronto, was also recently tapped to screen at the Austin Film Festival in October. Fox Searchlight will release the pic nationwide on Dec. 5.

The AFI Fest 2010 presented by Audi bows Nov. 4 in Hollywood.

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