Ray Liotta, Ving Rhames and Christian Slater are set to star in the indie “The River Sorrow.” Pic will be helmed by Rich Cowan from a script by Steve Anderson.

The pic centers on a detective, played by Liotta, on the trail of a serial killer. Slater will play an FBI agent overseeing the case while Rhames is Liotta’s friend and captain.

Gisele Fraga and Sarah Ann Schultz are also signed on. Cowan, Tay Voye, Dan Toll and Schultz will produce.

Richard Salvatore and Howard Kerbel exec produce. Pic begins lensing next week in Washington.

Liotta was most recently seen in “Date Night,” while Rhames can be seen in “Piranha 3D.”