Nick at Nite is the new boss of “Malcolm in the Middle.”

Cabler has acquired rerun rights to all 151 segs of the family comedy from Twentieth TV. “Malcolm” will become the anchor of Nick’s primetime sitcom block, airing Sunday-Thursday at 8 p.m. starting July 5.

Skein, which ran on Fox from 2000-06, revolved around a budding teenager, played by Frankie Muniz, with a genius IQ in a family of misfits. Jane Kaczmarek and Bryan Cranston co-starred as parents Lois and Hal.

Paul Ward, Nick’s exec veep of primetime acquisitions and strategy, said the series’ family-friendly appeal and youthful stars makes it a “perfect complement” for Nick at Nite’s laffer lineup, which includes “George Lopez,” “Home Improvement” and, starting in September, “Everybody Hates Chris.”

Created and exec produced by Linwood Boomer, “Malcolm” was an instant hit for Fox when it debuted in January 2000, and its success spurred the boom in recent years of single-camera comedies. It also boasted a catchy theme song by They Might Be Giants that featured the refrain “You’re not the boss of me, now.”

Reruns of “Malcolm” have been airing in broadcast syndication for the past few years.