The actress has come aboard to topline and exec produce the pic, which also stars Anna Paquin, Josh Duhamel, Malin Akerman, Elijah Wood, Adam Brody and Jeremy Strong.
Team Todd, Plum Pictures and Benaroya Pictures are producing.
Project, which had originally been scheduled to lense in the summer, begins shooting this week in New York.
Film revolves around eight friends from college who reunite for a wedding. Holmes, fresh off her role in Miramax’s “Don’t Be Afraid of the Dark,” will play Laura, the maid of honor to Anna Paquin’s Lila, the bride. Laura and Lila are best friends who both have a past with the groom (Duhamel).
Screenplay was adapted by Galt Niederhoffer from her novel; she will also direct.
Team Todd’s Jennifer and Suzanne Todd will produce alongside Plum Pictures’ Daniela Taplin Lundberg and Benaroya’s Michael Benaroya and Taylor Kephart.
Celine Rattray, Pam Hirsch and Riva Marker are also exec producing.
Simon Crowe from SC Films Intl. is selling foreign distribution.
Team Todd is in post-production on Tim Burton’s “Alice in Wonderland” for Disney.
Role marks Holmes’ first producing credit.