Lindsay Lohan will topline indie fantasy comedy “The Other Side” alongside Woody Harrelson, Giovanni Ribisi, Dave Matthews and Alanis Morissette.

Story centers on a grad student who must spend the summer working at a scientific institute on a remote island. She discovers an eccentric community of characters who are hiding a secret about a tragedy that took place many years before.

Shooting is set for October at an island off the coast of Massachusetts.

Feature role is Lohan’s first since “I Know Who Killed Me” in 2007, when her career stalled over assertions of unprofessional behavior.

“Lindsay’s very aware of people’s perceptions of her,” director David Michaels told Daily Variety. “She’s really committed to doing what she has to in order to change that.”

Producer Kent Harper said Lohan will be insured when lensing starts. She appeared in four episodes of “Ugly Betty” last year and will be seen later this year in the TV movie “Labor Pains.”

“The Other Side” is produced by Baudelaire, Film Star Pictures and Marston, with Jory Weitz (“Napoleon Dynamite”), Harper and Diane Isaacs producing. Michaels co-wrote the script with Phil Reeves.

Michaels will also serve as an exec producer with John Molli, Anthony Yohe and Doug Claybourne (“Nights in Rodanthe,” “North Country”).

Project’s been in development for three years. At one point, Brittany Murphy was attached along with Jason Lee, Ribisi, Jim Broadbent, Tim Roth and Lili Taylor.