NBC’s biggest new hope for fall, the Christian Slater drama “My Own Worst Enemy,” opened to mediocre numbers Monday.

The intriguing premise and fairly good reviews had NBC hoping for more from “Enemy,” but it settled for the fifth-best bow among the seven new dramas on the major nets this fall. It didn’t help, of course, that a show with male appeal went up against the Super Bowl champs on ESPN’s “Monday Night Football” and a tight baseball playoff game on Fox.

According to Nielsen “live plus same-day” estimates, “My Own Worst Enemy” averaged a 3.0 rating/8 share in adults 18-49 and 7.27 million viewers overall — placing third in the demo behind the football game and CBS vet “CSI: Miami.” It held 70% of its 18-49 lead-in from “Heroes” (4.3/10 in 18-49, 8.75m), similar to the bow of “Studio 60 on the Sunset Strip” two years ago.

Show declined by 10% among 18-49ers in its second half-hour (2.8 from 3.1) and held up best among women 25-54.

CBS won the night among the broadcasters, led by “Two and a Half Men” (5.3/12 in 18-49, 14.72m) and “CSI: Miami” (3.9/10, 13.22m). In between, “Worst Week” (3.2/7, 9.75m) again lost a big chunk of its lead-in, but nonetheless was again up week to week and edged out its rival timeslot comedy, “Samantha Who?” on ABC (3.0/7, 11.45m).

“Samantha,” which followed a relatively low-rated performance show edition of “Dancing With the Stars” (4.0/10, 17.77m), did draw more total viewers than “Worst Week” but was down sharply vs. its strong series bow at this time a year ago.

In the night’s sports showdown, ESPN fared better with its New York Giants-Cleveland Browns matchup on “Monday Night Football” (4.7/12, 11.42m) than Fox did with Game 4 of the National League Championship Series between the Philadelphia Phillies and Los Angeles Dodgers (2.5/7 in 18-49, 7.71m).

CW had another nice Monday with “Gossip Girl” (1.6/4 in 18-49, 3.31m) and “One Tree Hill” (1.7/4, 3.48m), winning the night among femmes 12-34 (3.5/9). “Hill” logged its best score among women 18-34 (3.9/10) in nearly two years.