Linwood Boomer is back in the family comedy biz.

The creator of “Malcolm in the Middle” is in final negotiations with CBS on a pilot order for a project that will reunite him with Gail Berman, the exec who shepherded “Malcolm” during her tenure at Regency TV and as programming chief at Fox.

Boomer wrote the script and will exec produce along with Berman and Lloyd Braun for their BermanBraun shingle and Universal Media Studios, where BermanBraun is based.

Dubbed “The Karenskys,” the multi-camera comedy revolves around a daughter’s return to the fold of her large, eccentric, ethnic family after her husband takes a job in her hometown.

The script was first set up at CBS a decade ago, at the same time that “Malcolm in the Middle” was picked up to series, so Boomer turned his attention to shepherding that show through its 2000-06 run on Fox.

Berman thought of “Karenskys” recently as she was surveying comedy prospects to develop for next year. CBS was quick to pounce on the project for a second time.

“I’d always kept this project in mind because the script was so good,” Berman said.

In addition to “Karenskys,” BermanBraun’s scripted slate includes the sci-fi drama “Virtuality” for Fox and the remake of “The Rocky Horror Picture Show” for MTV (Daily Variety, July 24).