New Line’s tapped D.J. Caruso to helm and Carl Ellsworth to write the comicbook adaptation “Y: The Last Man” for producers Chris Bender, JC Spink, Mason Novick and David Goyer.

Project reteams Caruso and Ellsworth following their work for Par/DreamWorks on “Disturbia.”

Story centers on a mysterious plague killing nearly all the world’s male mammals overnight. A magician who’s the only survivor among this group and his male pet monkey set out to find what may have wiped out the male chromosomes.

The comic “Y: The Last Man” was created by Pia Guerra and Brian K. Vaughn and published by Vertigo.

New Line-based Benderspink is also developing the adaptation of the comicbook “Power and Glory,” the comedy “Mancation” and remaking the Spanish franchise “Torrente” for New Line.