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This article was updated at 11:05 a.m.

Milo Ventimiglia, Lauren Lee Smith, Johnny Whitworth and Alyssa Milano have been cast in Lakeshore’s thriller “Pathology.”

Commercials director Mark Scholermann is making his feature helming debut. Lakeshore’s Tom Rosenberg and Gary Lucchesi will produce with Mark Neveldine and Brian Taylor.

Script, written by Neveldine and Taylor, is about a group of med students who hatch a scheme to see who can commit the perfect crime — one that even a fellow pathologist couldn’t unravel.

Production will begin in early May in Los Angeles. MGM will distribute the pic in the U.S. in late fall. Lakeshore will be selling international rights at Cannes.

Ventimiglia stars in NBC’s frosh hit drama “Heroes” and had a role in MGM’s “Rocky Balboa.”

Whitworth appears in the Weinstein Co.’s “Factory Girl” and Lionsgate’s upcoming “3:10 to Yuma.”

Milano starred in and produced the WB skein “Charmed.”

Smith recently wrapped Warner Bros.’ horror pic “Trick ‘r Treat” and has a role in Lakeshore’s “Elegy,” which is lensing. MGM will release.

Lakeshore also is in production on horror pic “Midnight Meat Train,” which Lionsgate will distribute, and “Untraceable,” set for a Screen Gems release.