Stanley Tucci and Campbell Scott had a big night Tuesday, as both thesps landed major pilot roles.

Tucci will star in CBS’ untitled drama about brain surgeons, while his “Big Night” co-director and co-star Scott is close to joining ABC’s “Six Degrees.”

Also, Andrew McCarthy will take another stab at TV, having hopped aboard CBS’ “The Way,” and John Cho has signed on to his next sitcom.

Tucci, next seen in “Lucky Number Slevin,” will star as Dr. Douglas Hanson, a brilliant but brash neurosurgeon, alongside Mark Feuerstein, Lorraine Toussaint and Reiko Aylesworth in the CBS pilot, from scribe Peter Ocko. CBS Paramount Network TV is producing.

He fills a role held by Dylan McDermott in a previous pilot for the project (McDermott is now in the ABC pilot “A House Divided”). Tucci’s TV credits include “Murder One” and telepic “The Life and Death of Peter Sellers.”

Meanwhile, Scott will reunite with Hope Davis – the duo starred in indie fave “The Daytrippers” (which also, coincidentally, featured Tucci) – for ABC drama pilot “Six Degrees,” about the intertwining lives of six New Yorkers.

Should it be picked up to series, “Six Degrees” would rep the first regular TV gig for Scott, whose feature credits also include “The Exorcism of Emily Rose.” Touchstone TV is behind the pilot.

McCarthy will star opposite Julia Ormond in “The Way,” which revolves around a powerful Boston family that dabbles in witchcraft.

Sony Pictures TV and CBS Paramount TV are behind the project. McCarthy’s last regular series role was on “Stephen King’s Kingdom Hospital.”

Cho (“Harold and Kumar Go to White Castle”) will star as Ivan on NBC laffer pilot “The Singles Table,” from 20th Century Fox TV. Thesp was last seen on the comedy “Kitchen Confidential.”

In other casting news:

— Rick Peters (“Close to Home”) has joined the cast of the CW’s “Aqua Man,” from Warner Bros. TV.

— Lauren Stamile (“Behind the Camera: Charlie’s Angels – The Untold Story”) will play Cassidy on Fox’s comedy pilot “That Guy,” from Regency TV. Eric Matheny (“Without a Trace”) is also aboard in the role of Trent.

— Jamie Denbo (“Reno 911”) has joined the cast of the Fox comedy pilot “Happy Hour,” from Warner Bros. TV.

— Laura Allen (“The 4400”) has been added to the FX pilot “Dirt.”

— Gill Gayle (“NYPD Blue”) will play Booney on the ABC comedy pilot “Southern Comfort,” from 20th Century Fox TV.