Ted Danson is back for another TV go, signing on to star in the ABC pilot “Help Me Help You,” while “Two and a Half Men” exec producer Chuck Lorre has lined up his next comedy project.

On the director front, Scott Winant (“Huff”) is set to helm Kevin Williamson’s untitled Palm Springs-set drama at the CW.

And in a flurry of castings Tuesday, Victor Garber has found post-“Alias” work, while Hope Davis (“American Splendor”) is joining the small-screen ranks.

In “Help Me Help You,” Danson will play a brilliant psychologist whose own life starts to unravel, partly in front of his group-therapy patients. Regency TV is behind the show, which comes from creators Jennifer Konner and Alexandra Rushfield (“Undeclared”).

Best known for his hit skeins “Cheers” and “Becker,” Danson has more recently been seen in the A&E telepic “Knights of South Bronx” and playing himself on “Curb Your Enthusiasm.”

Meanwhile, Lorre and Bill Prady (“Gilmore Girls”) are the writers and exec producers behind the CBS comedy pilot “The Big Bang Theory.”

Project, from Warner Bros. TV, revolves around two smart guys who encounter a woman and realize they actually know little about how the real world works. Lorre’s credits also include “Dharma & Greg,” where Prady also worked.

As for Winant, the “Huff” showrunner-exec producer has also directed episodes of that show, as well as “Carnivale” (which he also exec produced), “Dead Like Me,” “The Shield” and “The West Wing.” He helmed the pilot to Fox’s upcoming laffer “The Loop” and the feature “Til There Was You.”

In other pilot news:

  • Garber joins Rebecca Mader on Fox’s “American Crime,” which focuses on celebrity lawyers and their big-time cases. Warner Bros. TV and Bruckheimer TV are behind the pilot.

Beyond his stint as Jack Bristow on “Alias,” Garber appeared in ABC’s limited series “Empire” and miniseries “Life With Judy Garland: Me and My Shadows.” His feature credits include “Legally Blonde” and “Titanic.”

  • Davis will join Erika Christensen, Jay Hernandez and Dorian Missick on ABC’s “Six Degrees,” which comes from Touchstone TV and Bad Robot.

Project revolves around six New Yorkers who are strangers, but whose lives somehow interconnect. Davis’ other TV credits include the series “Deadline”; in film, she also starred in “Next Stop Wonderland” and “The Myth of Fingerprints.”

  • Tim McGowan (“The War at Home”) is set to play Bruce in CBS’ “Play Nice,” from CBS Paramount Network TV.

Show revolves around a brother and sister who run the family toy business. Thesp’s credits include a recurring role on “Everybody Loves Raymond” as well as the movies “After the Sunset” and “Ghost World.”

  • Sean Maguire (“Eve”) will join Jason Ritter, Lucy Punch, Heather Goldenhersh, Jon Bernthal, Andrea Anders and Jesse Ferguson on CBS’ “Class.”

Comedy pilot, from Warner Bros. TV, focuses on childhood classmates who reunite in their 20s. Maguire, who’s in second position to “Eve,” will play Kyle.

  • Michelle Hurd will play FBI Agent Lowry, while Chris Bauer is signed to play FBI Agent Dodd, on CBS’ “Smith.” Warner Bros. TV/John Wells pilot focuses on crimes from the criminal’s point of view; Ray Liotta, Virginia Madsen, Amy Smart and Franky G. also star.