Jon Avnet is set to direct action thriller “Second World,” which Emmett/Furla Films will produce with Avent’s Brooklyn Films.

Avent, who is in post-production on Al Pacino starrer “88 Minutes,” is skedded to begin shooting this fall. Cast has not been set.

“Second,” from a spec script by Scott King, revolves around a top assassin — and mother — who must stop a deadly virus from spreading. But in order to halt the potential pandemic, she must team up with the virus’ creator, who also is her target.

Producers are Randall Emmett, George Furla and Avnet.

Avent said the story is a “ride from beginning to end.”

Emmett/Furla Films expects to finance “Second World” through its production, financing and distribution deal with Avi Lerner and Danny Dimbort’s Millennium Films, which was recently reupped.

Avnet (“Fried Green Tomatoes,” “Red Corner”) also teamed with Emmett/Furla on “88 Minutes,” which was financed by Millennium. Before coming on to helm that project, Avent had been focusing more on producing than directing.

He produced feature films including “Sky Captain and the World of Tomorrow,” as well as stage productions “Spamalot” and “Pillowman.” Avnet will launch “History Boys” on Broadway this spring.

Emmett/Furla and Millennium’s latest film, Richard Donner’s “16 Blocks,” was released last weekend by Alcon Entertainment and Warner Bros. Alcon and Warners also will release Emmett/Furla and Millennium’s “The Wicker Man,” directed by Neil LaBute and starring Nicolas Cage.

Currently, Emmett/Furla and Millennium are lensing helmer Irwin Winkler’s Iraqi wartime drama “Home of the Brave,” and are in pre-production on Michael Douglas starrer “King of California,” which Michael Cahill will direct.