ABC cruised to another Sunday ratings victory behind dominant dramas “Desperate Housewives” and “Grey’s Anatomy” but Fox was also a strong second on the night with an hour of “The Simpsons” and the return of “Family Guy,” according to preliminary nationals from Nielsen.

At 9, “Desperate Housewives” (roughly 11.5 rating/25 share in adults 18-49, 26.2 million viewers overall) was the night’s (and week’s) No. 1 program in 18-49, approaching series records in the demo. And hot rookie “Grey’s Anatomy” established more highs at 10 (roughly 8.4/20 in 18-49, 18.1 million viewers overall), again topping CBS and NBC combined. Alphabet also won every half-hour in 18-49 from 7 to 9 with a special two-hour “Extreme Makeover: Home Edition” (4.8/14 in 18-49, 12.4 million viewers overall).

Over at Fox, its premiere of “Animation Domination” performed very well, highlighted by the strong relaunch at 9 for “Family Guy” (5.7/13 in 18-49, 11.9 million viewers overall), which more than doubled the net’s average in the timeslot this season and racked up a 27 share among males 12-34.

Back-to-back episodes of “The Simpsons” also scored for Fox (5.4/14 in 18-49, 11.1 million viewers overall for the hour), running second to “Home Edition” and leading its time period in key male demos. And at 9:30, the premiere of another animated laffer, “American Dad” (4.6/10 in 18-49, 9.5 million viewers overall), also ran second in 18-49.

Despite facing ABC’s femme-friendly lineup, CBS did solid numbers with its Hallmark Hall of Fame presentation “Riding the Bus With My Sister” (3.4/8, 11.2 million viewers overall), which grew with each half hour from 9 to 11.

NBC ran fourth on the night, led by “Law & Order: Criminal Intent” (3.4/7 in 18-49, 11.3 million viewers overall) and “Crossing Jordan” (3.4/8 in 18-49, 11.1 million viewers overall).

Preliminary 18-49 averages: ABC, 7.4/19; Fox, 4.5/12; CBS, 3/8; NBC, 2.8/7; WB, 1.2/3.

In total viewers: ABC, 17.3 million; CBS, 14.5 million; Fox, 9.3 million; NBC, 9.1 million; WB, 2.6 million.