Life imitated art last week, as the cast of HBO’s “Entourage” partied Hollywood style at the Roosevelt Hotel for the series’ soph-season premiere.

Like the too-cool-for-school celebs portrayed on the show, exec producer Mark Wahlberg rushed down the arrivals line and checked his watch while posing for photogs. At the after-party, Nicky Hilton (girlfriend of skein’s thesp Kevin Connolly) appeared more interested in IM’ing on her Sidekick than the festivities at hand, which included manicures and palm readings. And co-star Adrian Grenier nearly took on the persona of his cocky character, Vincent Chase, confidently stating, “It’s time for a new era of HBO comedy and we are it.” (Nevermind that only eight episodes have aired thus far.)

Despite the inside jokes and heavy emphasis on industry life, HBO chairman and CEO Chris Albrecht believes the show appeals to a wide audience. “I think men everywhere can relate to the bond between these guys,” he said. Jerry Ferrara, another “Entourage” member, added, “Hollywood is just the backdrop. It’s just the setting for the show, which is about four friends and the people that they are encountering.”

Others on hand for the bash included Jeremy Piven (the skein’s agent-in-residence), Gina Gershon, HBO Entertainment prexy Carolyn Strauss, Serena Williams, Lukas Haas and Thora Birch.