MADRID — Penelope Cruz is in advanced negotiations to topline the drama “Non ti muovere” (Don’t Move), the second film as a director from actor Sergio Castellito.

Castellito won the European Film Academy actor award last year for his perfs in “Bella Martha” (Mostly Martha) and “L’Ora di religione” (My Mother’s Smile).

Skedded to begin shooting in Rome in late July and based on a novel by Margarita Mazzantini, pic is co-produced by Italy’s Cattleya and Spain’s Alquimia Cinema. Castellito will star opposite Cruz.

Cruz would play Italia, a vulgar, introverted, working-class girl whom life has treated hard.

“Penelope wants to act more in Europe and was attracted to the quality of the film, working with Sergio Castellito and the role,” said Katrina Bayonas, whose Kuranda Intl. Management reps Cruz with CAA.

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Cruz acted in two Italian films early in her career, “La Ribelle” and “Per amore, solo per amore,” both made in 1993. In the latter pic, she played the Virgin Mary.

Castellito’s debut feature as a director was “Libero burro” (1999).