David Guion and Michael Handelman have been brought on by director Jay Roach to rewrite DreamWorks comedy “Used Guys.” Roach will direct, with Ben Stiller and Vince Vaughn starring.

Pic is among several candidates for the next directing vehicle for Roach, who last helmed “Austin Powers in Goldmember.” “Used Guys” was originally scripted by Mickey Birnbaum.

“It is set in the future, where women run the Earth,” Roach said. “Men killed themselves off by ingesting some kind of enhancement drink. Women now get cloned companions, and the two leads are rendered obsolete by a new clone line that promises to be sexier, better listeners and superior lovers.”

The dumped duo goes on the run, hoping to regain manhood by reaching a guy heaven known as “Mantopia.”

The Brillstein-Grey/UTA-repped Guion and Handelman wrote the comedy “Mondo Beyondo,” the Jimmy Fallon vehicle “Fast Track” and Disney animated pic “Low Lifes.”

“They came in and made me laugh hard, and in meetings that is not an easy thing to do,” Roach said. “It doesn’t guarantee great writing, but I’ve also seen the scripts they’ve written.”