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After 11 years, E! Entertainment’s “Talk Soup” is at a loss for words.

Strip, which helped make a star out Greg Kinnear, will stop production after its final episode airing Wednesday night.

“Talk Soup,” hosted by Aisha Tyler since January of last year, is calling its quits as the heyday of the chat shows it feasted on is fading. Sally Jessy Raphael and Rosie O’Donnell are signing off from their shows after this month; Oprah Winfrey has signaled her exit after the 2005-06 season.

E! exec VP of entertainment Mark Sonnenberg said the net decided to bow out while the show was still popular.

Tyler, who’s also host of syndie dating effort “The 5th Wheel,” praised E! for being “extraordinarily supportive.” Tyler recently nabbed a role in upcoming Tim Allen starrer “Santa Clause 2.”

Other “Talk” stirrers have included Hal Sparks, now co-starring in Showtime’s “Queer as Folk,” and John Henson. Debuting in 1991, “Talk Soup” was E!’s first breakout show. With Henson at the helm, the strip earned E! its first daytime Emmy for outstanding special class program in 1995. Since then, “Talk Soup” has been nominated four more times.