ABC has ordered 13 episodes of “The George Lopez Show,” a new sitcom from Warner Bros. TV, Bruce Helford and Sandra Bullock’s production company.

The comedy, which stars comedian and radio host Lopez as a family man in Los Angeles, will be prepped for a potential midseason bow. Bullock is on board to guest star in the show’s first episode; her Fortis Films shingle will produce along with Helford’s Mohawk Prods.

Besides Helford and Bullock, Deborah Oppenheimer (“Norm”) and Robert Borden (“The Brian Benben Show”) will executive produce. Helford, Borden and Lopez serve as co-creators.

“The opportunity to create with Bruce Helford and Sandy Bullock is a dream come true,” Lopez said. “The unfortunate part is I have to set aside my stem cell research.”

“George Lopez” will be ABC’s latest stab at reigniting the family comedy (along with “My Wife and Kids” and “According to Jim”), a once-dominant genre on the Alphabet web. The series will be set at home, where Lopez’s character lives with his wife, kids and grandmother, as well as at work, where he serves as a union rep at an airplane parts factory.

ABC and Warner Bros. hope to develop “George Lopez” in the vein of working-class family comedies such as “Roseanne,” which Helford exec produced and Borden helped write.

A friend of Bullock’s first brought Lopez to her attention. After watching Lopez’s stand-up routine, Bullock –whose company is based at Warner Bros. — met with Helford about collaborating on a series starring the comedian.

“Who would have thought that my life would go from ‘me me me’ to ‘George George George,’ ” Bullock said. “We are so excited to be part of the teaming of George and Bruce Helford.”

Lopez, who has just signed with UTA, was a morning personality on Los Angeles’ KCMG-FM (“Mega 92.3”) until that station underwent a format change last week. He’s still slated to host a Saturday morning show on the station.

Lopez currently appears in a recurring role on Showtime’s “Resurrection Blvd.” He also writes for Nickelodeon’s “The Brothers Garcia” and frequently hosts Univision’s “Que Loco.” Oglio Records/Warner Music recently released the standup’s CD “Right Now, Right Now.”

The comedian also took a dramatic turn in the Lions Gate film “Bread and Roses,” which premiered to strong reviews at the Cannes Film Festival. He’ll also appear in the Disney comedy “Frank McKlusky, C.I.” and the Showtime telepic “Fidel.”

Lopez is the first Latino thesp to headline a primetime sitcom since Constance Marie starred in NBC’s 1997 laffer “Union Square.”

Lopez is also repped by manager Ron De Blasio; UTA also reps Helford, Oppenheimer and Borden, while CAA handles Bullock.