Despite its chic, modernist lines and sky-high hip factor, this SoHo newcomer gets the restful residential tone just right. Rooms are custom comfortable and sexy without feeling faddish, baths are the most beautiful in town and alfresco lounge spaces abound. 60 Thompson St.; 877-431-4000 or www.60thompson.com; doubles from $370.
This brand-new David Rockwell-designed loft-style roost already counts Chris Rock among its fans. Unfinished concrete and cutting-edge art set the SoHo tone, while luxe fabrics and furniture add Fifth Avenue polish. 15 W. 56th St.; 212-974-5656 or www.chambers-ahotel.com; doubles from $425.
Bryant Park Hotel:
A stunning gilt-edged 1924 facade conceals unapologetically modern-minimalist interiors. High-ceilinged, B&B Italia-furnished rooms are less artsy, more clean-lined than those at Chambers. A screening room beckons to a film-and-fashion crowd. 40 W. 40th St.; 212-642-2200 or www.bryantparkhotel.com; doubles from $425.
Outfitted in a sumptuous neoclassical-meets-modern style, the Benjamin suits a discerning, grown-up crowd that wants 21st-century technology and boutique-style luxuries without the seemingly requisite party scene or hard-edge postmodern design. 125 E. 50th St.; 888-4-BENJAMIN or www.thebenjamin.com; doubles from $295.
The warm and welcoming Muse offers boutique-hotel intimacy without the steely modern design (and attitude) that usually goes hand in hand with the concept. Perks include the Sam DeMarco-helmed District for first-rate dining, plus 24-hour concierge service that makes everyone feel like a VIP. 130 W. 46th St.; 877-THE-MUSE or www.themusehotel.com; doubles from $305.
With its fab faux ’60s Scandinavian stylings and bold geometric patterns, this Gramercy Park newcomer brings high design to industry ladder-climbers whose expense accounts have limits — for now. 201 E. 24th St.; 212-696-3800 or www.nychotels.com; doubles from $165.
The latest Ian Schrager creation retains its status as ground zero for the It Crowd. The beautiful but tiny Philippe Starck-designed rooms are best for style hounds who value scene over ace. 356 W. 58th St.; 800-444-4786 or www.ianschragerhotels.com; doubles from $95.