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NEW YORK — George Clooney is in talks to star in “Unfaithful,” an Adrian Lyne-directed Fox 2000 drama inspired by the 1968 Claude Chabrol film “La Femme Infidel.”

Arnold and Anne Kopelson are producing. Bill Broyles wrote the script, with filming to begin early this fall.

“Unfaithful,” which was shepherded by Fox 2000 prexy Elizabeth Gabler and exec veep Carla Hacken, shapes up as his likely next project –the first of several he will film in the fall and winter.

Clooney would play a man who learns that his wife is cheating on him. The pic studies the ramifications of his discovery, and what adversity does to a loving relationship — themes Lyne explored in films like “Indecent Proposal” and “Fatal Attraction.” Fox 2000 is looking for an actress to pair opposite Clooney.

The actor also is part of a stellar ensemble that is shaping up for Warner Bros.’ remake of “Ocean’s Eleven,” to be directed by Steven Soderbergh and produced by Jerry Weintraub. Brad Pitt, Bruce Willis and Julia Roberts are among those negotiating to join him.

Clooney is also booked to star for director Danny DeVito in “Revelation,” a Warner Bros./Village Roadshow Pictures drama being produced by Mark Canton and exec produced by Bruce Berman. He’s set to play an internal affairs officer who takes a bullet during the attempted assassination of a cardinal. His search for the assassin parallels his own religious journey.

Upcoming are the Coen brothers’ “Oh Brother, Where Art Thou?” and WB’s “The Perfect Storm.”

Clooney is repped by CAA.