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Chris Cooper has signed to join the cast of the latest Farrelly brothers’ pic, “Me, Myself and Irene.”

Cooper, whose credits include “October Sky,” “Great Expectations” and “Lone Star,” will portray detective Joe Sarrasin in the Jim Carrey- Renee Zellweger starrer.

Cooper can also be seen this fall in the DreamWorks pic “American Beauty” with Kevin Spacey and Annette Bening.

The deal was negotiated by Cooper’s manager, Julie Yorn of Artists Management Group, and agent Michael Lazo of Paradigm.

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William Lee Scott joins Nicolas Cage, Angelina Jolie and Giovanni Ribisi in Disney’s “Gone in 60 Seconds,” from producer Jerry Bruckheimer and director Dominic Sena (“Kalifornia”).

Scott will play a young car thief in a gang of outlaws in the Scott Rosenberg-penned pic.

Scott has recently appeared in Universal’s “October Sky” and will next be seen in James Toback’s “Black & White.” He is repped by Endeavor and manager Felicia Sager.

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Tamala Jones has signed on as the female lead opposite Ice Cube in New Line’s “Next Friday,” the sequel to 1995’s “Friday.”

Multi-hyphenate Ice Cube, who wrote and starred in the first pic, will now serve as producer, along with Michael Gruber and Matt Alvarez.

Jones, a regular on WB’s “For Your Love,” can be seen on the bigscreen this summer opposite Taye Diggs and Omar Epps in Paramount’s “The Wood,” and with Martin Lawrence in Col’s “Blue Streak.”

Jones’ deal was brokered by Barry McPherson and Jeff Goldberg at Agency for the Performing Arts. She is also managed by Imparato Knight Fay Management.

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Regina King will appear alongside Ellen DeGeneres and Sharon Stone in HBO’s followup to “If These Walls Could Talk,” from exec producers Jennifer and Suzanne Todd. The latest is a three-story pic that focuses on the experiences of lesbians in America. Anne Heche wrote and will direct the segment, entitled “Miss Conception.”

King will play an employee of a local sperm bank in a seg that features a lesbian couple attempting to conceive a child.

King recently wrapped “Love and Action in Chicago” opposite Courtney B. Vance and Kathleen Turner. She has also had co-starring roles in “Enemy of the State,” “Jerry Maguire” and “How Stella Got Her Groove Back.” King is repped by Chuck James at the Gersh Agency and John Carrabino at Morey Management Group.

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Mili Avital has signed on as the female lead in noir thriller “Preston Tylk” from indie startup Next Generation.

Avital joins Luke Wilson, Norman Reedus and Dennis Farina in the pic about a man suspected of murdering his wife. Director Jon Bokencamp makes his feature debut on the pic, alongside the exec producing team of Brian Sullivan and Kevin Morris and producers James Frey, Dan Glasser and Roni Eguia.

Avital has appeared in “Kissing a Fool” and “Polish Wedding.” She was repped on the deal by CAA and her manager, Myrna Jacoby of MJ Management.

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Spyglass Entertainment’s “Shanghai Noon” continues to bolster its cast with latest additions Xander Berkeley and Jason Connery. The thesps join stars Jackie Chan, Lucy Liu and Owen Wilson in the Tom Dey-directed actioner.

Berkeley has previously appeared in “Amistad,” “Air Force One” and “Gattaca.” He is repped by Susan Smith and Associates and Mark Armstrong of Sanders Management.

Connery was previously seen in “The Secret Life of Ian Fleming” and the upcoming “An Urban Ghost Story.” He is repped by Danielle Galiana-Allman and Daniel DoTy of Inneract Entertainment.

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Oliver Hudson has been added to the cast of the indie pic “The Smokers,” about three rebellious boarding school girls who are frustrated with their respective suitors.

Christina Peters wrote and will direct the pic; Nicholas Loeb produces. Lensing is skedded to begin next month in Wisconsin.

Hudson made his bigscreen debut recently in Par’s remake of “The Out-of-Towners,” alongside mom Goldie Hawn, and is shooting MGM’s “Mary Jane’s Last Dance” with Dominique Swain, Taye Diggs and Mia Kirschner. Hudson is repped by Todd Eisner and Chris Schmidt of Writers and Artists, and David Seltzer of Industry Entertainment.