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TORONTO — John Sayles’ latest film, “Men With Guns,” will be screened as a world premiere gala presentation at the Toronto Intl. Film Festival, which runs Sept. 4-13.

In making the announcement Monday, festival organizers said Agnieszka Holland’s “Washington Square” will also make its debut.

“Men With Guns,” which Sayles wrote, directed and edited, is the story of a Latin American doctor who trains young physicians to bring modern medicine to Indian tribes in the jungle. When something goes wrong, he journeys into the jungle in an adventure that echoes Joseph Conrad’s “Heart of Darkness,” festival programmers said.

The cast includes Federico Luppi, Dan Rivera Gonzalez, Damian Alcazar, Damian Delgado, Mandy Patinkin and Katheryn Grody. Produced by Maggie Renzi and R. Paul Miller, the film will be distributed Stateside by Sony Pictures Classics.

“Washington Square,” James’ critique of social mores in 19th century New York, has been adapted for the screen by Carol Doyle and stars Jennifer Jason Leigh, Albert Finney, Maggie Smith, Ben Chaplin and Judith Ivey.

The film is produced by Hollywood Pictures/Caravan Pictures in association with Alchemy Filmworks and distributed by Buena Vista.

North American audiences first discovered Holland at the Toronto festival, which screened the world premiere of her film “Europa Europa” in 1990.