2D comicbook sequel debuted with an estimated $133.6 million at 4,380 engagements.
The "Black" installment will reteam Smith and director Barry Sonnenfeld.
"Iron Man 2" scored an estimated $133.6 million in its opening weekend.
Paramount and Marvel Entertainment mounted an aggressive international rollout of "Iron Man 2," with boffo results over the April 30-May 2 weekend at the international box office.
Hollywood is officially kicking off the summer with a foreign accent.
Sony announced "Men in Black III" will get the 3D treatment set for release May 25, 2012.
"Iron Man 2" got off to a sizable start this weekend, with midnight grosses totaling $7.5 million.
The franchise sequel opened to $100.2 million in 53 overseas markets.
After a boffo international rollout last weekend, "Iron Man 2" is primed to kick off a socko summer Stateside.
The studio is still tight-lipped on whether "Breaking Dawn" will be one or two films.
Domestic Film DAILY
PROVIDED BY: Box Office
Captain America: The Winter Soldier
Captain America: The Winter Soldier1Daily:$4.3M Cumulative:$174.9M Disney 22.52%
Rio 22Daily:$3.6M Cumulative:$52.9M Fox 17.90%
Heaven is for Real
Heaven is for Real3Daily:$3.3M Cumulative:$7.0M Sony / TriStar -10.21%