His mother, Elizabeth, confirmed the news on Facebook.
“Dear family and friends, it is with a heavy heart that I share this devastating news,” she wrote. “My beloved and cherished son, Nathaniel Marston, who was putting up the good fight until last night was not able to continue due to the traumatic and devastating nature of his injuries. Nathaniel passed away peacefully as I held him in my arms.”
Marston had been in critical condition after the serious crash in Reno, Nevada, in which he suffered a broken neck and back.
The actor is best known for his role as Michael McBain on “One Life To Live.” He also appeared on “As the World Turns” until 1999.
He is survived by his mother and wife, Rita.