Elisha Cuthbert
George Pimentel/WireImage

Elisha Cuthbert (“Happy Endings,” “24”) has been cast in the lead role of Lizzy in the NBC/WBTV comedy pilot “One Big Happy.”

The Peacock’s new comedy revolves around Lizzy (Cuthbert), who plays a lesbian, and her straight male best friend, Luke (Nick Zano), who have been living together and have been trying to have a baby via artificial insemination. They finally get pregnant — just as Luke meets and impulsively marries the love of his life, Prudence.

Ellen DeGeneres, Liz Feldman, Scott Ellis and Jeff Kleeman will be executive producers. Feldman will also serve as scribe while Ellis directs the pilot.

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