Lily Collins is also on board with Christian Ditter directing.
Based on the Liz Tuccillo novel, the story centers on a woman living in New York and searching for love. Marc Silverstein and Abby Kohn have penned the adaptation, with Dana Fox working on the latest draft.
Michael Disco and Dave Neustadter are overseeing “How to Be Single” for New Line.
Best known for her TV work on “Mad Men” and the recently canceled “Community,” Brie has a handful of bigscreen projects coming out this next year. She co-stars in the Warner Bros. comedy “Get Hard” opposite Will Ferrell and indie “Sleeping With Other People” with Jason Sudeikis.
The actress is repped by WME and Sloane Offer Weber Dern.