With four films bowing this year, Marisa Tomei is as busy as ever, with no rest on the horizon: The Oscar winner just signed on to play Billy Crystal and Bette Midler’s daughter in Andy Fickman’s family comedy “Us and Them.”

The co-production of 20th Century Fox and Walden Media will be produced by Chernin Entertainment’s Peter Chernin and Dylan Clark, as well as Crystal. Samantha Sprecher, who came up with the story with Crystal, will exec produce.

“Us and Them” stars Crystal and Midler as grandparents who struggle to cope with their grandkids’ modern ways when they’re left to care for them. The duo forge a new bond with their grandkids and set out to repair a long-standing rift with their daughter, Alice, to be played by Tomei.

Bailey Madison (“Don’t Be Afraid of the Dark”) is set to co-star as one of the three grandchildren.

“City Slickers” scribes Lowell Ganz and Babaloo Mandel wrote the current draft of the script, originally written by Lisa Addario and Joe Syracuse. Production is skedded to start later this month in Atlanta.

Tomei, who recently co-starred in “Crazy, Stupid, Love,” “The Lincoln Lawyer” and “Salvation Boulevard,” will soon be seen as a tenacious reporter in George Clooney’s political thriller “The Ides of March,” which Sony opens Oct. 7.

Tomei is repped by CAA and Untitled Entertainment.

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