MADRID — Juan Carlos Fresnadillo’s “Intruders,” toplining Clive Owen, Carice van Houten, Daniel Bruhl and Pilar Lopez-Ayala and Kerry Fox, will open the 59th San Sebastian Festival, the biggest film meet in the Spanish-speaking world.“Intruders” will screen as an opening gala Sept. 16. A psychological drama-thriller turning ultimately on the family, “Intruders” tells two parallel tales of a young girl in London, terrified by a childhood demon, Hollowface, who returns to threaten her and her family, and that of a mother in Spain, attempting to protect her son from a faceless stranger. “Intruders” “reflects my love of the demons buried in our unconscious,” said Fresnadillo. San Sebastian’s pulling down “Intruders” looks like a coup for its new director Jose Luis Rebordinos, and a mark of one direction he wants the Spanish festival to go in – towards broader-audience genre fare from name auteurs. Fresnadillo’s follow-up to “28 Weeks Later,” and one of the most awaited Spanish productions of the year, “Intruders” is produced by Universal Pictures Intl., Enrique Lopez Lavigne and Belen Atienza’s Madrid-based shingle Apaches Ent., and Antena 3 Films, the film arm of Spanish broadcaster Antena 3. UPI distributes “Intruders” worldwide. The San Sebastian Festival still has to announce whether “Intruders” plays in Competition.