Astin, Oteri in the saddle of indie movie

Sean Astin and Cheri Oteri are toplining independent comedy “And They’re Off,” set in the world of thoroughbred horse racing.

The ensemble cast includes Martin Mull, Mark Moses, Gigi Rice, Lil’ JJ, Peter Jacobson, Mo Collins, Alex Rocco, Luis Chavez and Kevin Nealon.

Horse trainers Bob Baffert and Doug O’Neill will play themselves in the pic.

Astin portrays a failed horse trainer desperately trying to get back into the winners circle. The film’s launching production this week with shooting at Hollywood Park in Los Angeles and the Fairplex in Pomona.

And They’re Off” is directed by Rob Schiller (“King of Queens,” “Two and a Half Men”) from a script by Alan Grossbard. Producers are Grossbard (“Zerophilia”), Pamela Fryman (“How I Met Your Mother”) and Howard Bolter.

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