Matty Beckerman’s finance and production shingle Natural Selection has set helmer Stephen T. Kay (“The Shield,” “Friday Night Lights”) to direct thriller pic “Isolation.”Pic, which began lensing Jan. 25, stars Eva Amurri (“Californication”) and David Harbour (“Revolutionary Road”). Amurri plays a medical student who awakens in a hospital isolation room having been losexposed to an unknown disease, desperately ill and with no recollection of how she got there. Natural Selection is fully financing the pic and producing with David Greathouse, Principal Entertainment’s Danny Sherman and Josh Kesselman, as well as John Baca. Chris Billett has penned the screenplay. Beckerman will produce and oversee production for Natural Selection. Kesselman and Sherman will oversee production for Principal. WME Global’s Graham Taylor is handling North American sales while international sales will be handled by Stuart Ford through IM Global’s genre label Octane. Beckerman formed Natural Selection last June to provide equity funding for a slate of some 20 films over the next five years with budgets of $15 million and under. Natural Selection’s other projects include Paul Scheuring’s “The Experiment,” starring Adrien Brody and Forrest Whitaker, produced by Inferno and based on the Mario Giordano novel.