Nicole Holofcener to helm Reiser adaptation

James McAvoy has checked into Mandate Pictures’ comedic adaptation of the Will Reiser novel “I’m With Cancer.” Nicole Holofcener will direct, and the pic will co-star Seth Rogen, who is also producing.

In the first major project McAvoy has agreed to star in since the Universal comicbook actioner “Wanted” and its upcoming sequel, thesp will play a 25-year-old who learns he has cancer and successfully battles the disease over several years.

Character is based on the real experiences of screenwriter Will Reiser, who won his own fight with cancer in his mid-20s.

Reiser penned the script for the yet-to-be-titled film; Holofcener will begin lensing in January.

Helmer, who broke out with the indies “Walking and Talking” and “Lovely and Amazing” before the Jennifer Aniston pic “Friends With Money,” recently completed “Please Give,” which she wrote and directed. Sony Pictures Classics will release the film next spring; Catherine Keener, Rebecca Hall and Amanda Peet star.

Rogen is producing the “Cancer” adaptation with his writing partner Evan Goldberg and former “Daily Show” exec producer Ben Karlin.

It will be the first pic Rogen and Goldberg have produced together. They penned the Judd Apatow-produced laffers “Superbad” and “Pineapple Express” and were executive producers on those films. They’re also exec producing actioner “The Green Hornet” at Sony.

Reiser serves as executive producer on “I’m With Cancer” along with Mandate prexy Nathan Kahane. Mandate’s Tendo Nagenda will co-produce.

McAvoy’s credits also include Fox Searchlight’s drama “The Last King of Scotland” and Focus Features’ “Atonement.”

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