Warner Bros. has set Alex Holmes to rewrite and direct “The Interpretation of Murder,” an adaptation of the Jed Rubenfeld novel.Paula Weinstein is producing. Story follows a Sigmund Freud protege who discovers a trail of sadistic murders in turn-of-the-century New York. Chris Kyle wrote the first draft of the screenplay. The novel was published in 2007 by Picador. Deal marks the first studio project for Holmes, who co-wroe, helmed and was exec producer of “House of Saddam,” a dissection of the ruthless reign of Iraqi leader Saddam Hussein. The mini aired on HBO in the U.S. Holmes is repped by ICM.