Vince Vaughn and Jon Favreau star.
Story follows four couples who go to a tropical island resort, where they discover that participation in the resort’s couples therapy is not optional.
Reno will play a therapist and operator of the resort.
Favreau penned the comedy that Peter Billingsley is helming. Jason Bateman, Kristen Bell, Malin Akerman, Kristin Davis and Faizon Love round out the cast.
Reno also will co-star in “Pink Panther 2” and “Armored,” the latter alongside Laurence Fishburne.
Vaughn is producing “Couples Retreat” with Scott Stuber.