'Grey's Anatomy' actor set for comedy

Eric Dane will be moonlighting from “Grey’s Anatomy” to take a co-starring role alongside Owen Wilson, Jennifer Aniston and Alan Arkin in “Marley & Me,” Fox 2000′s adaptation of John Grogan’s bestselling memoir. David Franklin is directing.

Wilson plays the ambitious reporter who moves with his wife (Aniston) to Miami for a newspaper job. Dane will play the journo’s best friend, who suggests that the reporter adopt a puppy as a substitute for the children his wife wants to have. Marley morphs from an adorable Lab puppy into an incorrigible handful.

Pic shoots in Miami this month. Gil Netter and Karen Rosenfelt produce; Don Roos and Scott Frank wrote the script.

Dane’s last movie was “X-Men: The Last Stand.”

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