'Grey's' actress to be featured in Spyglass comedy

“Grey’s Anatomy” star Katherine Heigl will topline the romantic comedy “27 Dresses.”

Scripted by “The Devil Wears Prada” screenwriter Aline Brosh McKenna, “27 Dresses” will be directed by Anne Fletcher.

Spyglass is financing the film, and Roger Birnbaum, Gary Barber and Jonathan Glickman will produce. Production begins in New York and Rhode Island in May when Heigl goes on hiatus from the series.

Heigl will play a single woman who has served as a bridesmaid 27 times. She is enlisted once again for the job, and this time it’s particularly painful: Her sister is marrying the man the bridesmaid is madly in love with.

McKenna originally hatched the project with producer Bobby Newmyer, who died in 2005. He will be the film’s exec producer, and Erin Stam will be co-producer.

Dana Fox (“The Wedding Date”) did a rewrite of McKenna’s original script, and McKenna is returning to do a final pass before production begins.

Heigl considered several offers after buzz began building on “Knocked Up,” the Judd Apatow-directed Universal comedy in which Heigl stars with Seth Rogen.

Fletcher made her directing debut on the dance hit “Step Up,” which she also choreographed.

Heigl’s repped by Paradigm, Fletcher by UTA.

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