Joe and Anthony Russo will direct “You, Me and Dupree” for Universal Pictures. Owen Wilson will star in the comedy, about a best man who stays on as a houseguest with the newlywed couple, ultimately wearing out his welcome. “Dupree” has been a high-priority project for Universal since the studio paid seven figures for Mike LeSieur’s “Dupree” script earlier this year. Wilson will also produce. Studio is eyeing a start date later this year, possibly as early as August.